Title:
アシルアミノ置換された環式カルボン酸誘導体及び医薬としてのその使用
Document Type and Number:
Japanese Patent JP5847088
Kind Code:
B2
Abstract:
The present invention relates to compounds of the formula I, wherein A, Y, Z, R20 to R22 and R50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
Inventors:
Joseph Pernerstorfer
Heinz-Werner Klemann
Matthias Schaefer
Arena safaroba
Marcel Patek
Heinz-Werner Klemann
Matthias Schaefer
Arena safaroba
Marcel Patek
Application Number:
JP2012537183A
Publication Date:
January 20, 2016
Filing Date:
November 02, 2010
Export Citation:
Assignee:
SANOFI
International Classes:
C07C235/54; A61K31/196; A61K31/335; A61K31/337; A61K31/343; A61K31/351; A61K31/357; A61K31/36; A61K31/381; A61K31/382; A61K31/404; A61K31/415; A61K31/4418; A61K31/455; A61P3/00; A61P5/00; A61P5/14; A61P7/00; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P25/02; A61P25/18; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P37/02; A61P37/08; A61P43/00; C07C307/06; C07C317/46; C07C323/19; C07D209/04; C07D209/12; C07D213/64; C07D213/82; C07D305/06; C07D309/14; C07D313/04; C07D317/68; C07D317/72; C07D319/20; C07D333/16; C07D333/38; C07D335/02; C07D493/08
Domestic Patent References:
| JP2009505962A | ||||
| JP2007210997A | ||||
| JP2008519761A | ||||
| JP52059644A | ||||
| JP2011524893A |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi