アシルチオウレア化合物又はその塩、及びその用途

Japanese Patent JP4667537

B2

To provide an antitumor agent which exhibits excellent c-Met inhibitory effect and mitigates side effects by virtue of selectively affecting to tumor cells in which c-Met is specifically expressed. The invention provides an acylthiourea compound represented by formula (I): (wherein each of R 1 and R 2 , which may be the same or different, represents a hydrogen atom, an optionally substituted C 1-6 alkyl group, an optionally substituted C 3-10 cycloalkyl group, an optionally substituted C 6-14 aromatic hydrocarbon group, or an optionally substituted saturated or unsaturated heterocyclic group, or R 1 and R 2 may form, together with the nitrogen atom to which they are attached, an optionally substituted nitrogen-containing heterocyclic ring; R 3 represents a C 1-6 alkyl group; and each of R 4 , R 5 , and R 6 , which may be identical to or different from one another, represents a hydrogen atom, a halogen atom, an optionally substituted C 1-6 alkyl group, a C 1-6 alkoxy group, a C 1-6 alkylamino group, an optionally substituted aromatic hydrocarbon group, or an optionally substituted saturated or unsaturated heterocyclic group, or R 5 and R 6 may form a ring together with the phenyl ring to which they are attached) or a salt thereof.

Etsuko Suda
Kosuke Egami
Hidenori Fujita

JP2010507175A

April 13, 2011

April 09, 2009

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Taiho Pharmaceutical Co., Ltd.

C07D215/48; A61K31/47; A61K31/4709; A61K31/5355; A61K31/55; A61P35/00; C07D401/12; C07D405/12; C07D409/12

JP2005272474A

2005-10-06

WO2005121125A1	2005-12-22
WO2006108059A1	2006-10-12
WO2006104161A1	2006-10-05

Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto

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