A2A受容体活性を有するアデノシン誘導体

Title:

A2A受容体活性を有するアデノシン誘導体

Document Type and Number:

Japanese Patent JP2008534447

Kind Code:

A

Abstract:

Compounds of (I) or stereoisomers or pharmaceutically acceptable salts thereof, where W, R¹, R², R³and R⁴have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the adenosine A_2Areceptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

Inventors:

Robin Alec Fairhurst
Roger John Taylor

Application Number:

JP2008501210A

Publication Date:

August 28, 2008

Filing Date:

March 13, 2006

Export Citation:

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Assignee:

NOVARTIS AG

International Classes:

C07H19/167; A61K31/7076; A61P11/06; A61P11/08; A61P11/14; A61P29/00; A61P43/00; C07D473/00; C07D473/16

Domestic Patent References:

JP2003506461A	2003-02-18
JP2005501842A	2005-01-20
JP2008526911A	2008-07-24

Foreign References:

WO2005020885A2

2005-03-10

Other References:

JPN6012018608; Ｂｉｏｏｒｇ．　Ｍｅｄ．　Ｃｈｅｍ．　Ｌｅｔｔ．Ｖｏｌ．１２, 2002, ｐｐ．２９３５-２９３９
JPN6012018611; Ｃｈｅｍ．　Ｐｈａｒｍ．　Ｂｕｌｌ．Ｖｏｌ．２３，　Ｎｏ．４, 1975, ｐｐ．７５９-７７４
JPN6012018613; Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．Ｖｏｌ．４７，　Ｎｏ．１９, 2004, ｐｐ．４７６６-４７７３
JPN5008001522; ＳＡＳＡＫＩ　Ｙ: ＮＵＣＬＥＩＣ　ＡＣＩＤＳ　ＳＹＭＰＯＳＩＵＭ　ＳＥＲＩＥＳＮ８, 19800821, Ｐ１６３-１６６, ＩＲＬ　ＰＲＥＳＳ
JPN5008001523; ＷＡＮＮＥＲ，　ＭＡＲＴＩＮ　Ｊ．: ＪＯＵＲＮＡＬ　ＯＦ　ＴＨＥ　ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹ，　ＰＥＲＫＩＮ　ＴＲＡＮＳＡＣＴＩＯＮＳ　１Ｎ１６, 2001, Ｐ１９０８-１９１５
JPN6012018614; Ｊ．　Ｍｅｄ．　Ｃｈｅｍ．Ｖｏｌ．１６，　Ｎｏ．１０, 1973, ｐｐ．１１８８-１１９０
JPN6012018616; Ｊ．　Ｏｒｇ．　Ｃｈｅｍ．Ｖｏｌ．５３，　Ｎｏ．１７, 1988, ｐｐ．３９５９-３９６７
JPN5008001526; ＷＡＮＮＥＲ　Ｍ　Ｊ: ＮＵＣＬＥＯＳＩＤＥＳ，　ＮＵＣＬＥＯＴＩＤＥＳ　ＡＮＤ　ＮＵＣＬＥＩＣ　ＡＣＩＤＳＶ２３　Ｎ８／９, 2004, Ｐ１３１３-１３２０, ＴＡＹＬＯＲ　＆　ＦＲＡＮＣＩＳ

Attorney, Agent or Firm:

Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi

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