Title:
アデノウイルス製剤
Document Type and Number:
Japanese Patent JP5118798
Kind Code:
B2
Abstract:
The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and/or vaccine applications. Especially preferred viral formulations disclosed herein are liquid adenovirus formulations, which show improved stability when stored in about the 2-8°C range while also being compatible with parenteral administration. These formulations comprise a buffer, a sugar, a salt, a divalent cation, a non-ionic detergent, as well as a free radical scavenger and/or a chelating agent to inhibit free radical oxidation.
Inventors:
Evans, Robert Kay
Bolkin, David Bee
Bolkin, David Bee
Application Number:
JP2001564789A
Publication Date:
January 16, 2013
Filing Date:
March 06, 2001
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
A61K9/08; A61K35/76; A61K9/00; A61K39/235; A61K47/00; A61K47/02; A61K47/10; A61K47/18; A61K47/26; A61K47/34; A61K47/46; A61K48/00; A61P31/12; A61P37/00; A61P39/06; A61P43/00; A61K39/00
Domestic Patent References:
| JP2000500026A | ||||
| JP2002503484A |
Foreign References:
| WO1999062500A1 | ||||
| WO1999011764A1 |
Other References:
Japanese Journal of Medical Science and Biology,1994年,Vol.47 ,pp.157-166
感染症学雑誌,1981年,pp.355-366
感染症学雑誌,1981年,pp.355-366
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Katsuma Osaki
Takamasa Soma
Mitsuru Inoue
Akio Ichiiri
Katsuma Osaki
Takamasa Soma
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