Title:
アフィニティークロマトグラフィー装置
Document Type and Number:
Japanese Patent JP6882410
Kind Code:
B2
Abstract:
The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody. The chromatography device may contain a stacked membrane assembly or a wound membrane assembly. The membrane assemblies include at least one polymer membrane that contains therein inorganic particles. The polymer membrane and/or the inorganic particles have an affinity ligand bonded thereto. The affinity ligand may be a protein, an antibody, or a polysaccharide that reversibly binds to the targeted protein or antibody. The chromatography device may be repeatedly used and may be cleaned with a caustic solution between uses. The chromatography devices may have a dynamic binding capacity (DBC) of at least 30 mg/ml (or 0.07 micromol/ml) at 10% breakthrough at a residence time of 20 seconds or less.
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Inventors:
Michael Sea. McManaway
Application Number:
JP2019182796A
Publication Date:
June 02, 2021
Filing Date:
October 03, 2019
Export Citation:
Assignee:
W.L. GORE & ASSOCIATES, INCORPORATED
International Classes:
B01J20/281; B01D15/38; B01J20/24; B01J20/28; B01J20/282; B01J20/283; B01J20/285; G01N30/60; G01N30/88
Domestic Patent References:
| JP4232852A | ||||
| JP1120903U | ||||
| JP7500363A | ||||
| JP6308109A |
Foreign References:
| WO2015052465A1 |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Satoshi Deno
Atsushi Ebiya
Naori Kota
Tatsunori Ikeda
Shinji Mitsuhashi
Satoshi Deno
Atsushi Ebiya
Naori Kota
Tatsunori Ikeda