Title:
AGENT FOR CONTROLLING DEATH OF CELL
Document Type and Number:
Japanese Patent JP3931022
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide an agent for controlling death of the cell, by. adding a volume-sensitive Cl- (chloride ion) channel blocker, because cell contraction recognized in case of apoptosis is controlled when the action of the Cl- channel is controlled by the blocker, and various apoptosis reactions thereafter are inhibited, and consequently the death of the cell is controlled.
SOLUTION: This agent for controlling death of the cell contains the volume- sensitive Cl- channel blocker as an active ingredient, wherein the volume- sensitive Cl- channel blocker preferably comprises at least one kind of compound selected from a group comprising stilbene derivatives (4-acetamido-4'- isothiocyanatostilbene-2,2'-disulfonate and 4,4'-diisothiocyano-2,2'- stilbenedisulfonate), a carboxylic acid derivative [5-nitro-2-(3-phenylpropylamino)- benzoic acid], niflumic acid, glibenclamide, and fluothylene.
Inventors:
Yasunobu Okada
Emi Maeno
Emi Maeno
Application Number:
JP2000192838A
Publication Date:
June 13, 2007
Filing Date:
June 27, 2000
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
A61K31/05; C12Q1/02; A61K31/121; A61K31/18; A61K31/196; A61K31/245; A61K31/275; A61K31/4406; A61K31/64; A61K45/00; A61P9/04; A61P9/10; A61P25/28; A61P43/00; C12N5/07; C12N5/071; (IPC1-7): A61K45/00; A61K31/121; A61K31/18; A61K31/196; A61K31/275; A61K31/4406; A61P9/04; A61P9/10; A61P25/28; A61P43/00; C12N5/06; C12Q1/02
Domestic Patent References:
| JP4234329A | ||||
| JP4504579A | ||||
| JP9508270A |
Foreign References:
| WO2000002578A1 | ||||
| WO1999012559A1 |
Other References:
Life Sciences,1993年,Vol.53, No.15,1211-15
Journal of Pharmacology and Experimental Therapeutics,1996年,Vol.278, No.3,pp.1012-17
Invetigative Ophthalmology & Visual Science,1996年,Vol.37, No.4,pp.619-29
Journal of Pharmacology and Experimental Therapeutics,1996年,Vol.278, No.3,pp.1012-17
Invetigative Ophthalmology & Visual Science,1996年,Vol.37, No.4,pp.619-29
Attorney, Agent or Firm:
Yusuke Hiraki