Title:
ALBUMIN FUSION PROTEIN
Document Type and Number:
Japanese Patent JP2015120714
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for treating, preventing, or improving diseases, disorders, or conditions, using a pharmaceutical composition comprising an albumin fusion protein, and an albumin fusion protein as a means for solving the problem of storing unstable protein molecules.SOLUTION: The invention provides a pharmaceutical composition comprising an albumin fusion protein comprising GLP-1 (7-36 (A8G)) oriented with two tandems fused to the N terminal of human albumin comprising the amino acid sequence of a specific sequence ID number through a C terminal thereof, for using it in combination with at least one treatment for internal secretion or hormone imbalance disorder. At least one treatment for internal secretion or hormone imbalance disorder is selected from insulin, metformin, pioglitazone, and the like, and is used for manufacture of a medicament for treating diabetes.
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Inventors:
ROSEN CRAIG A
HASELTINE WILLIAM A
RUBEN STEVEN M
HASELTINE WILLIAM A
RUBEN STEVEN M
Application Number:
JP2015007992A
Publication Date:
July 02, 2015
Filing Date:
January 19, 2015
Export Citation:
Assignee:
HUMAN GENOME SCIENCES INC
International Classes:
A61K38/00; C12N15/09; A61K31/155; A61K31/426; A61K31/517; A61K31/64; A61K38/28; A61K39/395; A61K45/00; A61P3/10; A61P5/00; A61P7/06; A61P13/12; A61P19/06; A61P35/00; A61P43/00; C07H21/04; C07K14/47; C07K14/76; C07K14/765; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/04
Domestic Patent References:
| JPH07503368A | 1995-04-13 | |||
| JP2000502901A | 2000-03-14 |
Foreign References:
| WO2001079271A1 | 2001-10-25 |
Other References:
"Biological Activities of Glucagon-Like Peptide-1 Analogues in Vitro and in Vivo", BIOCHEMISTRY, vol. 40, no. 9, JPN6015049634, 7 February 2001 (2001-02-07), pages 2860 - 2869, ISSN: 0003214494
"Biological activity of GLP-1-analogs with N-terminal modifications", REGULATORY PEPTIDES, vol. vol.79,no.2,3, JPN6015049636, 1999, pages 93 - 102, ISSN: 0003214495
"Biological activity of GLP-1-analogs with N-terminal modifications", REGULATORY PEPTIDES, vol. vol.79,no.2,3, JPN6015049636, 1999, pages 93 - 102, ISSN: 0003214495
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Hiroshi Yamazaki
Kenji Tomita
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