PURPOSE: To provide an alcohol absorption suppressing agent containing beet saponin as an active component, effective for suppressing the alcohol concentration in blood to suppress the development of uncomfortable symptom such as drunken sickness and suitable for preventing the harmful influence of drink by reducing the load on the liver, etc.
CONSTITUTION: This suppressing agent contains a beet saponin consisting of oleanolic acid 3-O-β-D-glucopyranoside uronic acid ester of formula as an active component. The compound of formula can be produced by extracting dried beet pulp with a sodium hydroxide solution under heating, treating the extracted liquid with a UF membrane having a fractionation molecular weight of 20,000, acidifying the permeated liquid, separating the precipitate by centrifugal separation, drying and crushing the separated solid to obtain a crude beet saponin and separating and purifying the crude product by silica gel column chromatography. The suppressing agent is administered to an adult by oral administration before drinking at a rate of 20-100mg/dose in terms of the weight of the compound of formula.
YAMAHARA JOJI
YOSHIKAWA MASAYUKI
YABUUCHI TAKAHIRO
