PURPOSE: To provide novel alicyclic compounds exhibiting activities as alicyclic phospholipase A2 inhibitors and useful as anti-inflammatory agents.
CONSTITUTION: The compound of formula I [wherein the bonds between C2 and C3, and/or between C4 and C5 are unsaturated; X represents COOH, H, a halogen, COR'', CONH2, CR''', CHO, CH2OH, OH, OR''', CF3, 1-6C (halo)alkyl, NO2, P(O)(OH)2, SO2H or the like; R represents a substituted or unsubstituted alkyl, aryl, arylalkyl, alkenyl or arylalkenyl (these radicals each has 6 ore more carbons), but R is not a radical of formula II]; R' represents H or a 1-6C alkyl; R'' represents R', C(R3)2OC(O)R4, CH2CH2NR5R6 or the like; R''' represents a 1-6C alkyl; R3 represents H, CH3, C2H5 or the like; R4 represents a 6-12C aryl or 1-7C alkyl; R5 and R6 are each a 1-3C alkyl or 3-6C cycloalkyl by joining together, CH2CH2OCH2CH2], for example (2Z),(4Z)-4-(3- carboxyphenyl)-5-(5,6,7,8-tetrahydro-5,5,8,8-tetra-methyl-2-naphthalenyl)-2,4- pentadienic acid, is provided.
EFU AIBUII KIYARORU
KIYASARIN EMU GURIIN
ANITA REUIN
MUZAMIRU EMU MANSURI
SUTANRII BUII DANDOREA
