Title:
ファルネソイドＸ受容体モジュレーターとしてのアルケンスピロ環化合物
Document Type and Number:
Japanese Patent JP7223016
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (I), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
Inventors:
Von Jien Singh
Chunjiang Liu
Yantin Juan
Chunjiang Liu
Yantin Juan
Application Number:
JP2020544332A
Publication Date:
February 15, 2023
Filing Date:
October 31, 2018
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D261/08; A61K31/42; A61K31/422; A61K31/437; A61K31/4439; A61K31/444; A61K31/4709; A61K31/496; A61K31/502; A61P1/16; A61P1/18; A61P3/00; A61P3/06; A61P3/10; A61P13/12; A61P29/00; A61P35/00; A61P43/00; C07D413/04; C07D413/06; C07D413/12; C07D413/14; C07D417/14; C07D471/04; C07D513/04
Foreign References:
| WO2017118294A1 | ||||
| WO2016096115A1 | ||||
| WO2016096116A1 | ||||
| CN106146483A | ||||
| WO2017027312A1 |
Attorney, Agent or Firm:
Yamato Kento
Shinagawa
Wu Yingyan
Futami Kamahira
Masahiro Suwon
Shinagawa
Wu Yingyan
Futami Kamahira
Masahiro Suwon
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