Title:
アルコキシベンゾ五員（六員）複素環式アミン化合物およびその医薬用途
Document Type and Number:
Japanese Patent JP7475049
Kind Code:
B2
Abstract:
The invention relates to alkoxybenzeno five- or six-member heterocyclic amines compounds as scheme I , in which the R1, R2 and R3 are consistent with the detailed description in the patent claim. The compounds can act as selective sphingomyelin synthase 2 (SMS2) inhibitors to treat diseases caused by abnormal increasing of sphingomyelin (SM). This invention also includes compounds as scheme I , including pharmaceutically acceptable salts, pharmaceutical compositions as the active ingredients, and their application in drugs which can prevent and cure diseases caused by abnormal increasing of SM. These diseases caused by abnormal increasing of SM include atherosclerosis, type II diabetes, fatty liver, obesity, metabolic syndromes, enteritis and other inflammatory diseases.
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Inventors:
Ye, Daeyoung
Mo, Mingwang
Yang, Jinton
Zhou, Lou
Ju, Yong
Faye, Jinyu
Ki, Shanyu
Mo, Mingwang
Yang, Jinton
Zhou, Lou
Ju, Yong
Faye, Jinyu
Ki, Shanyu
Application Number:
JP2020542775A
Publication Date:
April 26, 2024
Filing Date:
January 21, 2019
Export Citation:
Assignee:
Fudan University
International Classes:
C07D413/12; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/4725; A61K31/506; A61K31/5377; A61P1/04; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P9/10; A61P29/00; A61P39/02; A61P43/00; C07D231/54; C07D261/20; C07D275/04; C07D401/12; C07D417/12
Domestic Patent References:
| JP11506728A | ||||
| JP2010111624A | ||||
| JP2008543956A | ||||
| JP2011502958A | ||||
| JP2005530711A | ||||
| JP2007523937A | ||||
| JP2017529333A |
Foreign References:
| WO2008089310A2 | ||||
| WO2008089307A2 | ||||
| CN101993382A |
Other References:
CAS Registry No.2186218-29-9,DATABASE REGISTRY [online],Entered STN,2018年03月07日
MO, Mingguang et al.,J.Med.Chem.,2018年,61,8241-8254
QI, Xiang-Yu et al.,Bioorg.Med.Chem.Lett.,2017年,27,3511-3515
DENG, Xiaodong et al.,Eur.J.Med.Chem.,2014年,73,1-7
MO, Mingguang et al.,J.Med.Chem.,2018年,61,8241-8254
QI, Xiang-Yu et al.,Bioorg.Med.Chem.Lett.,2017年,27,3511-3515
DENG, Xiaodong et al.,Eur.J.Med.Chem.,2014年,73,1-7
Attorney, Agent or Firm:
IBC Ichibancho Patent Attorney Corporation
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