Title:
ヒストンデアセチラーゼの阻害活性を有するアルキルカルバモイルナフタレニルオキシオクテノイルヒドロキシアミド誘導体およびその製造方法
Document Type and Number:
Japanese Patent JP2009513697
Kind Code:
A
Abstract:
This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.
Inventors:
Li Cholhe
Jun Hee Jun
Kim Jae Hak
John wonjan
Cho Jung Mun
Ro Song
Hyun Younglan
Shin Dongkyu
Li Chulson
Jun Hee Jun
Kim Jae Hak
John wonjan
Cho Jung Mun
Ro Song
Hyun Younglan
Shin Dongkyu
Li Chulson
Application Number:
JP2008538811A
Publication Date:
April 02, 2009
Filing Date:
October 31, 2006
Export Citation:
Assignee:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
International Classes:
C07C259/06; A61K31/165; A61K31/341; A61K31/381; A61K31/40; A61K31/4015; A61K31/417; A61K31/44; A61K31/445; A61K31/4453; A61K31/495; A61K31/5375; A61K31/5377; A61P35/00; A61P43/00; C07D207/12; C07D207/14; C07D211/16; C07D211/58; C07D213/75; C07D233/61; C07D295/12; C07D295/18; C07D307/14; C07D307/66; C07D333/20; C07B61/00
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa