ALKYNE DERIVATIVES AND PROCESS FOR PREPARATION THEREOF

Title:

ALKYNE DERIVATIVES AND PROCESS FOR PREPARATION THEREOF

Document Type and Number:

Japanese Patent JPS523028

Kind Code:

A

Abstract:

Alkyne compounds of the formula wherein R1 is H, alkyl of up to 4 carbon atoms or phenyl; R2 is H, aliphatic acyl of up to 6 carbon atoms or aroyl of up to 11 carbon atoms; R3 and R4 are H, F, Cl or Br and n is 0 or 1, and physiologicaly acceptable metals salts thereof, have antiinflammatory activity. These compounds can be made from compounds of the formula wherein Q is a functionally-modified hydroxy and R1, R3, R4 and n are as above by treatment with a solvolyzing agent.

Inventors:

YOAHIMU GANTE
HANSU ADORUFU KUURUMAIAA
DEIITAA ORUTSU EERITSUHI SHIYA
ARUBUREHITO BUIRUTSU

Application Number:

JP7270076A

Publication Date:

January 11, 1977

Filing Date:

June 18, 1976

Export Citation:

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Assignee:

MERCK PATENT GMBH

International Classes:

A61K31/065; A61K31/085; A61K31/215; A61K31/22; A61P3/06; A61P7/02; A61P25/04; A61P29/00; C07C27/00; C07C69/007; C07C29/42; C07C33/28; C07C33/48; C07C41/00; C07C43/295; C07C67/00; C07C69/145; C07F1/00; (IPC1-7): C07C33/06; C07C33/10; C07C43/20; C07C69/02; C07C69/62; C07C69/76

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