Title:
アロイル-ピペリジン誘導体
Document Type and Number:
Japanese Patent JP4564846
Kind Code:
B2
Abstract:
The invention relates to a method of administering N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formula wherein Y is ═N— or ═N(O)—, R is OH when Y is ═N— and R is H when Y is ═N(O)— and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, provided that when R is OH and Y is ═N— the ring A is not unsubstituted, for the treatment of disorders induced by substance P, such as: pain, migraines, anxiety, vomiting, schizophrenia, depression; motor disorders such as Parkinson's disease, inflammatory diseases such a rheumatoid arthritis, iritis and conjunctivitis, diseases of the respiratory organs such as asthma and chronic bronchitis, diseases of the gastrointestinal system such as ulcerative colitis and Crohn's disease, and hypertension.
Inventors:
Seem Jacob Fernstra
Application Number:
JP2004535464A
Publication Date:
October 20, 2010
Filing Date:
September 09, 2003
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D401/12; A61K31/4709; A61P1/00; A61P1/04; A61P1/08; A61P9/12; A61P11/00; A61P11/06; A61P19/02; A61P25/00; A61P25/02; A61P25/06; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P27/02; A61P29/00; A61P43/00; C07B57/00; C07B63/00
Domestic Patent References:
| JP7196649A | ||||
| JP2002220386A | ||||
| JP61000015A |
Foreign References:
| WO2002012192A1 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima