Title:
ALPHA (1,3) GALACTOSYL TRANSFERASE-NEGATIVE SWINE
Document Type and Number:
Japanese Patent JP2007175057
Kind Code:
A
Abstract:
To provide a method for preventing the production of carbohydrate moieties having a distinctive terminal Galα1-3Galβ1-4GlcNAc epitope that is a significant factor in human transplant rejection.
Provided is a swine in which the normal expression of α(1,3) galactosyltransferase is prevented in at least one organ of tissue type by using a DNA construct encoding an antisense RNA and a DNA encoding a ribozyme.
Inventors:
BAETSCHER MANFRED W
SACHS DAVID H
GUSTAFSSON KENTH T
SACHS DAVID H
GUSTAFSSON KENTH T
Application Number:
JP2007026119A
Publication Date:
July 12, 2007
Filing Date:
January 10, 2007
Export Citation:
Assignee:
BIOTRANSPLANT INC
GEN HOSPITAL CORP
UNIV LONDON
GEN HOSPITAL CORP
UNIV LONDON
International Classes:
A01K67/027; C12N15/09; C07H21/04; C12N9/10; C12N15/113; C12N15/85; A61K35/12
Attorney, Agent or Firm:
Norio Saeki
Akio Ichiiri
Akio Ichiiri
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