NEW MATERIAL:The compound of formulaI(R1 is alkyl, phenyl or benzothiazolyl; R2 is alkyl).
EXAMPLE: α-Chloro-α-(methylthio)propionic acid ethyl ester.
USE: Synthetic intermediate of a profen compound of formula III useful as an antiphlogistic, analgesic and antipyretic agent.
PROCESS: The compound of formulaIis prepared by treating the compound of formula II with a chlorinating agent (e.g. N-chlorosuccinimide, sulfuryl chloride, Cl, chlorinated isocyanuric acid, etc.) in a non-polar solvent (e.g. carbon tetrachloride, methylene chloride, chloroform, etc.). The reaction and the separation are carried out at a low temperature, i.e. -10W+60°C. A profen compound of formula III (Ar is 6-methoxy-naphth-2-yl, etc.) is obtained by treating the compound of formulaIand a specific aromatic compound with a catalyst such as stannic chloride, followed by reductive desulfurization and hydrolysis.
OBARA YOSHIO
TAKAKUWA YASUO
IIIZUMI TOYOKO
| US3946071A | 1976-03-23 |
Next Patent: NOVEL N-(ARYLALKYL)-2-(SUBSTITUTED PHENYL)ETHYLAMINE DERIVATIVES AND MANUFACTURE