Title:
アミド化合物および抗腫瘍剤としてのその使用
Document Type and Number:
Japanese Patent JP2010520915
Kind Code:
A
Abstract:
The present invention relates to a compound of Formula (I), its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from CONHOH, CONHCH2SH, CONHCH2SCOCH3, SH, SCOCH3, SCH3, N(OH)COH, COCONHCH3 and CF3 for the preparation of a medicament, in particular for selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells, for inducing differentiation of tumor cells in a tumor, for inhibiting the activity of histone deacetylase and for the treatment of primary cancer or secondary cancer.
Inventors:
Stephen Heinshan
Luciana Autzas
Giuseppe Giannini
Claudio Pisano
Loredana Vesi
Walter Kaburi
Luciana Autzas
Giuseppe Giannini
Claudio Pisano
Loredana Vesi
Walter Kaburi
Application Number:
JP2009553140A
Publication Date:
June 17, 2010
Filing Date:
March 12, 2008
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
C07C259/06; A61K31/167; A61K31/395; A61K31/407; A61K31/4162; A61K31/4353; A61P35/00; A61P35/02; A61P43/00; C07D273/01; C07D273/02; C07D498/04
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga