Title:
NMDA受容体の選択的拮抗薬としてのアミジン誘導体
Document Type and Number:
Japanese Patent JP2004501136
Kind Code:
A
Abstract:
A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, in particular neuropathic pain and headache, specifically migraine, whils displaying fewer ataxic and related side-effects associated with other classes of NMDA receptor antagonists.
Inventors:
Carteis, Neil Roy
Krakowski, Janusyu Josef
Thomas, Steve
Watt, Alan Paul
Krakowski, Janusyu Josef
Thomas, Steve
Watt, Alan Paul
Application Number:
JP2002504218A
Publication Date:
January 15, 2004
Filing Date:
June 14, 2001
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
C07D333/20; A61K31/155; A61K31/341; A61K31/381; A61K31/4409; A61P9/00; A61P9/10; A61P21/02; A61P25/00; A61P25/04; A61P25/08; A61P25/22; A61P25/28; A61P29/02; A61P43/00; C07C257/14; C07D213/36; C07D213/40; C07D307/52; (IPC1-7): C07C257/14; A61K31/155; A61K31/341; A61K31/381; A61K31/4409; A61P9/00; A61P9/10; A61P21/02; A61P25/00; A61P25/04; A61P25/08; A61P25/22; A61P25/28; A61P29/02; A61P43/00; C07D213/36; C07D307/52; C07D333/20
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki