Title:
アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法
Document Type and Number:
Japanese Patent JP7280248
Kind Code:
B2
Abstract:
The present invention provides an amidite compound represented by formula (1) which enables a synthesis of RNA with high purity, and the method for preparing a polynucleotide by using the same compound. (In the formula (1), wherein R represents the following formula (wherein Ra and Rb are identical to or different from each other and each represents a methyl group, an ethyl group, or a hydrogen atom, with the proviso that Ra and Rb does not represent a hydrogen atom. n is an integer of 1 to 5), and Ba represents a group containing optionally protected nucleobase structure, and G1 and G2 are identical to or different from each other and each represents a protecting group for a hydroxy group, and G3 are identical to or different from each other and each represents an alkyl group.
Inventors:
Yuki Tanaka
Tatsuya Saito
Hideki Ihara
Tatsuya Saito
Hideki Ihara
Application Number:
JP2020515487A
Publication Date:
May 23, 2023
Filing Date:
April 23, 2019
Export Citation:
Assignee:
Sumitomo Chemical Co., Ltd.
International Classes:
C07H19/10; C07C319/20; C07C321/14
Domestic Patent References:
| JP2016050203A | ||||
| JP5554881B2 |
Foreign References:
| WO2012073857A1 | ||||
| WO2011034072A1 | ||||
| WO2013027843A1 |
Attorney, Agent or Firm:
Michiko Matsutani
Sei Morimoto
Sei Morimoto