Title:
AMIDO COMPOUND AND ITS USE AS PHARMACEUTICAL
Document Type and Number:
Japanese Patent JP2013151519
Kind Code:
A
Abstract:
To provide new and improved drugs that target 11βHSD1 and/or MR.
This invention relates to a compound represented by the following formula [I], wherein: Cy is aryl, heteroaryl, cycloalkyl or heterocycloalkyl, each optionally substituted by 1, 2, 3, 4 or 5-W-X-Y-Z; R1 and R2 together with the C atom to which they are attached form a 3-, 4-, 5-, 6- or 7-membered cycloalkyl group or a 3-, 4-, 5-, 6- or 7-membered heterocycloalkyl group; and R3 and R4 together with the N atom to which they are attached form a 4-15 membered heterocycloalkyl group optionally substituted by 1, 2, 3, or 4-W'-X'-Y'-Z'.
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Inventors:
YAO WENQING
ZHOU JINCONG
XU MEIZHONG
ZHANG COLIN
METCALF BRIAN
HE CHUNHONG
QIAN DING-QUAN
ZHOU JINCONG
XU MEIZHONG
ZHANG COLIN
METCALF BRIAN
HE CHUNHONG
QIAN DING-QUAN
Application Number:
JP2013044576A
Publication Date:
August 08, 2013
Filing Date:
March 06, 2013
Export Citation:
Assignee:
INCYTE CORP
International Classes:
C07D209/44; A61K31/401; A61K31/403; A61K31/4035; A61K31/404; A61K31/407; A61K31/41; A61K31/4196; A61K31/422; A61K31/425; A61K31/4365; A61K31/437; A61K31/438; A61K31/4418; A61K31/4439; A61K31/445; A61K31/451; A61K31/454; A61K31/47; A61K31/472; A61K31/473; A61K31/495; A61K31/496; A61K31/497; A61K31/4985; A61K31/506; A61K31/537; A61P3/00; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P19/10; A61P25/28; A61P27/06; A61P29/00; A61P43/00; C07D207/06; C07D207/08; C07D207/10; C07D207/12; C07D207/14; C07D207/16; C07D207/263; C07D207/30; C07D209/08; C07D209/42; C07D209/52; C07D209/62; C07D209/70; C07D211/16; C07D211/18; C07D211/22; C07D211/34; C07D211/46; C07D211/48; C07D211/52; C07D211/58; C07D211/64; C07D211/66; C07D211/70; C07D213/38; C07D215/08; C07D217/06; C07D217/26; C07D221/00; C07D221/10; C07D221/20; C07D223/02; C07D223/04; C07D231/04; C07D295/18; C07D295/185; C07D333/34; C07D401/04; C07D401/06; C07D401/10; C07D401/14; C07D403/04; C07D405/04; C07D405/14; C07D409/04; C07D413/10; C07D413/14; C07D417/04; C07D471/04; C07D471/10; C07D487/04; C07D487/08; C07D487/10; C07D491/10; C07D491/107; C07D491/20; C07D493/10; C07D495/04; C07D498/10; C07D498/20; C07D513/10; A61K31/40
Domestic Patent References:
| JP5265913B2 | 2013-08-14 | |||
| JPS57156450A | 1982-09-27 | |||
| JP2004509103A | 2004-03-25 | |||
| JP2003506432A | 2003-02-18 | |||
| JP2002519429A | 2002-07-02 | |||
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| JP2006503034A | 2006-01-26 | |||
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| JP2006521275A | 2006-09-21 |
Foreign References:
| WO2003049736A1 | 2003-06-19 | |||
| WO2003006364A2 | 2003-01-23 |
Other References:
JPN6011043820; Ｆｒａｎｃｏｉｓ ＬＥＹＥＮＤＥＣＫＥＲ， Ｄｏｍｉｎｉｑｕｅ ＬＡＵＣＨＥＲ: 'Ｕｓｅ ｏｆ （２Ｓ，４Ｒ）-ｈｙｄｒｏｘｙｐｒｏｌｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ ａｓ ｌｉｇａｎｄｓ ｉｎ ｃｈｉｒａｌ ｃｏｐｐｅｒ（Ｉ） ｃｏｍｐｌｅｘｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．２４， Ｎｏ．３３, 1983, ｐ．３５１７-３５２０, Ｅｌｓｅｖｉｅｒ Ｂ． Ｖ．
JPN6011043820; Ｆｒａｎｃｏｉｓ ＬＥＹＥＮＤＥＣＫＥＲ， Ｄｏｍｉｎｉｑｕｅ ＬＡＵＣＨＥＲ: 'Ｕｓｅ ｏｆ （２Ｓ，４Ｒ）-ｈｙｄｒｏｘｙｐｒｏｌｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ ａｓ ｌｉｇａｎｄｓ ｉｎ ｃｈｉｒａｌ ｃｏｐｐｅｒ（Ｉ） ｃｏｍｐｌｅｘｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．２４， Ｎｏ．３３, 1983, ｐ．３５１７-３５２０, Ｅｌｓｅｖｉｅｒ Ｂ． Ｖ．
JPN6011043820; Ｆｒａｎｃｏｉｓ ＬＥＹＥＮＤＥＣＫＥＲ， Ｄｏｍｉｎｉｑｕｅ ＬＡＵＣＨＥＲ: 'Ｕｓｅ ｏｆ （２Ｓ，４Ｒ）-ｈｙｄｒｏｘｙｐｒｏｌｉｎｅ ｄｅｒｉｖａｔｉｖｅｓ ａｓ ｌｉｇａｎｄｓ ｉｎ ｃｈｉｒａｌ ｃｏｐｐｅｒ（Ｉ） ｃｏｍｐｌｅｘｅｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．２４， Ｎｏ．３３, 1983, ｐ．３５１７-３５２０, Ｅｌｓｅｖｉｅｒ Ｂ． Ｖ．
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Yasushi Ochiai
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