Title:
AMINE-CONTAINING TRANSFECTION REAGENTS AND METHODS FOR MAKING AND USING THE SAME
Document Type and Number:
Japanese Patent JP2022184875
Kind Code:
A
Abstract:
To provide novel amine-containing transfection compounds for in vitro and in vivo delivery of biologically active agents, and methods for making and using the same.SOLUTION: An amine-containing transfection compound is represented by formula I. [X1 and X2 are each O, S, NH, N-C1-20 alkyl, or the like; Y and Z are each C=O, C=S, S=O, CH-OH, or SO2; R1 to R7 are H, an aliphatic group, or the like; x is an integer from 1 to 10; n is an integer from 1 to 3; m is an integer from 0 to 20; and p is 0 or 1.]SELECTED DRAWING: None
Inventors:
YANG ZHIWEI
PARUL ANGRISH
XAVIER DE MOLLERAT DU JEU
KRISTIN WIEDERHOLT
WU TAO
PARUL ANGRISH
XAVIER DE MOLLERAT DU JEU
KRISTIN WIEDERHOLT
WU TAO
Application Number:
JP2022141466A
Publication Date:
December 13, 2022
Filing Date:
September 06, 2022
Export Citation:
Assignee:
LIFE TECHNOLOGIES CORP
International Classes:
C07C229/12; A61K31/7088; A61K31/7105; A61K31/711; A61K31/713; A61K38/02; A61K47/54; A61K48/00; A61P43/00
Domestic Patent References:
| JP2009501699A | 2009-01-22 | |||
| JP2010505873A | 2010-02-25 | |||
| JP6383480B2 | 2018-08-29 | |||
| JP6807900B2 | 2021-01-06 | |||
| JP7138692B2 | 2022-09-16 |
Foreign References:
| WO2010062322A2 | 2010-06-03 | |||
| WO2010053572A2 | 2010-05-14 |
Other References:
AKINC, AKIN ET AL.: "A combinatorial library of lipid-like materials for delivery of RNAi therapeutics", NATURE BIOTECHNOLOGY, vol. 26(5), JPN6015027392, 2008, pages 569 - 1, ISSN: 0005155643
PNAS, vol. Vol.107(5), JPN6021040141, 2010, pages 1869 - 1864, ISSN: 0005155644
ADVANCED FUNCTIONAL MATERIALS, vol. Vol.19(19), JPN6023038735, 2009, pages 3112 - 3118, ISSN: 0005155645
PNAS, vol. Vol.107(5), JPN6021040141, 2010, pages 1869 - 1864, ISSN: 0005155644
ADVANCED FUNCTIONAL MATERIALS, vol. Vol.19(19), JPN6023038735, 2009, pages 3112 - 3118, ISSN: 0005155645
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto