AMINE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONIST ACTIVITY

Title:

AMINE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONIST ACTIVITY

Document Type and Number:

Japanese Patent JP2009221230

Kind Code:

A

Abstract:

To provide a new compound having NPY Y5 receptor antagonist activity.

The compound of formula (I): R1-Y-N(-R2)-X-N(-R7)-Z [wherein R1 is an optionally substituted lower alkyl; Y is -S(O)n- (wherein n is 1 or 2) or -CO-; R2 is hydrogen or a lower alkyl; R7 is hydrogen or a lower alkyl; X is a lower alkylene, a lower alkenylene, an arylene, a cycloalkylene or the like; and Z is a lower alkyl, an optionally substituted hydrocarbon cyclic group, an optionally substituted heterocyclic group or the like], a pharmaceutically acceptable salt or a solvate thereof is provided.

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Inventors:

OKUNO TAKAYUKI
KAMIYAMA NAOKI
SAKAGAMI MASAHIRO

Application Number:

JP2009160438A

Publication Date:

October 01, 2009

Filing Date:

July 07, 2009

Export Citation:

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Assignee:

SHIONOGI & CO

International Classes:

C07C311/07; A61K31/18; A61K31/40; A61K31/402; A61K31/415; A61K31/4164; A61K31/4184; A61K31/42; A61K31/423; A61K31/425; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4402; A61K31/4436; A61K31/4439; A61K31/445; A61K31/455; A61K31/47; A61K31/472; A61K31/4965; A61K31/50; A61K31/501; A61K31/502; A61K31/505; A61K31/5375; A61K31/5377; A61K31/538; A61K31/553; A61P1/14; A61P3/04; A61P9/04; A61P9/10; A61P9/12; A61P15/00; A61P15/10; A61P25/08; A61P25/20; A61P25/24; A61P43/00; C07C317/36; C07D207/27; C07D207/325; C07D211/26; C07D213/36; C07D213/38; C07D213/74; C07D213/85; C07D215/22; C07D215/38; C07D217/22; C07D231/38; C07D233/61; C07D235/30; C07D237/20; C07D237/22; C07D237/34; C07D239/42; C07D241/20; C07D261/14; C07D261/20; C07D263/56; C07D263/58; C07D265/30; C07D265/36; C07D267/14; C07D275/02; C07D277/28; C07D277/62; C07D277/82; C07D295/12; C07D295/18; C07D403/04; C07D409/04; C07D413/04; C07D413/06; C07D417/04; C07D417/12; C07D498/04; C07D513/04

Domestic Patent References:

JP2002543067A	2002-12-17
JP2003503486A	2003-01-28
JP2004503462A	2004-02-05
JP3910446B2	2007-04-25

Foreign References:

WO2001037826A1	2001-05-31
WO2006001318A1	2006-01-05

Attorney, Agent or Firm:

Kenichi Sugita
Hiromitsu Takayama

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