Title:
アミノ酸誘導体
Document Type and Number:
Japanese Patent JP5422557
Kind Code:
B2
Abstract:
Compounds of formula (I) or formula (II) have dopaminergic activity: wherein: R1 is a carboxyl, carboxyl ester, or carboxamide group; R2 is a group —C(═O)—NR3R4, or —S(═O)2—NR3R4; R3 and R4 are independently selected from hydrogen, optionally substituted C1-C6 alkyl, (C1-C5 fluoroalkyl)-CH2—, -Q, and —CH2Q, wherein Q is an optionally substituted monocyclic carbocyclic or heterocyclic ring of (3) to (6) ring atoms; or R3 and R4 together with the nitrogen to which they are attached form an optionally substituted monocyclic cycloalkyl or non-aromatic heterocyclic ring of (3) to (8) ring atoms; R5 is hydrogen, or a natural or non-natural alpha amino acid residue linked via a peptide bond; R6 is hydrogen or a group R7C(═O)—; and R7 is C1-C6 alkyl, C1-C6 fluoroalkyl or cyclopropyl.
Inventors:
Hobbs, christopher
Application Number:
JP2010514127A
Publication Date:
February 19, 2014
Filing Date:
July 04, 2008
Export Citation:
Assignee:
PROXIMAGEN LTD.
International Classes:
C07C271/44; A61K31/22; A61K31/40; A61P25/00; A61P25/16; A61P25/20; A61P35/00; A61P43/00; C07C307/02; C07C309/25; C07D207/00
Domestic Patent References:
| JP2096556A | ||||
| JP54022337A |
Foreign References:
| GB1347375A | ||||
| US3859331 |
Attorney, Agent or Firm:
Shintaro Nogawa