AMINO ACID DERIVATIVE

Japanese Patent JPH02279661

A

NEW MATERIAL: A compd. represented by formula I (wherein R1 is an alkoxycarbonyl, an alkanoyl, an aralkanoyl or an acyl group of an amino group- substd. α-amino acid, R2 is an alkyl or an aralkyl, R3 is H or an alkyl, R4 is an alkyl, one of R5 and R6 is H and the other one of them is H, an alkyl, an aryl or an aralkyl, one of W and X is H and the other one of them is H or NH2, Y is H, or further OH when one of W and Y is H and the other one of them is OH) and its acid addition salt.

EXAMPLE: N2-[5(S)-(t-butoxyformamide)-6-cyclohexyl-4(S)-hydroxy-2(S)- isopropylhexanoyl]-N1-phenetyl-L-isoleucineamide.

USE: A drug for treating or preventing virus infections, especially, HIV infection.

PROCESS: For example, a compd. represented by formula II or III is treated with an acid to obtain the corresponding compd. represented by formula I.

KUIRIKO BURANKA
ARUBUREHITO EDENHOFUAA
JIYOSEFU AAMUSUTORONGU MAATEIN
JIYON HAABAATO MERETSUTO
BERUNAA NAITOHARUTO

JP5193190A

November 15, 1990

March 05, 1990

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HOFFMANN LA ROCHE

A61K31/27; A61K31/335; A61K31/357; A61K31/42; A61K31/421; A61K31/47; A61K31/472; A61P31/12; C07C211/08; C07C211/36; C07C229/30; C07C233/88; C07C237/22; C07C251/36; C07C271/22; C07D213/40; C07D217/06; A61K31/195; C07D233/26; C07D263/04; C07D295/12; C07D295/13; C07D295/20; C07D295/205; C07D317/30; C07D405/12; C07D413/12; C07F7/18; C07K1/113; C07K5/02; C07K5/06; A61K38/00; (IPC1-7): A61K31/195; A61K31/27; A61K31/335; A61K31/42; A61K31/47; C07C211/08; C07C211/36; C07C229/30; C07C233/88; C07D217/06; C07D263/04; C07D295/12; C07D295/20; C07D317/30; C07D405/12; C07D413/12; C07F7/18; C07K5/06

Heikichi Odashima

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