Title:
糖尿病の治療又は予防のためのジペプチジルペプチダーゼＩＶ阻害剤としてのアミノテトラヒドロピラン
Document Type and Number:
Japanese Patent JP5734981
Kind Code:
B2
Abstract:
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Inventors:
Bifto, Tessfei
Chain pin
Fen, Dunkin
Kian, Shaosha
Chain pin
Fen, Dunkin
Kian, Shaosha
Application Number:
JP2012527901A
Publication Date:
June 17, 2015
Filing Date:
August 23, 2010
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D487/04; A61K31/155; A61K31/4162; A61K31/4439; A61P3/10; A61P43/00
Domestic Patent References:
| JP5537507B2 | ||||
| JP4854825B2 |
Foreign References:
| WO2007126745A1 | ||||
| WO2007136603A1 | ||||
| WO2007097931A1 | ||||
| WO2009014676A1 |
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Kenji Ando
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Kenji Ando