To obtain a novel aminoalcohol derivative that has excellent therapeutic effect on neurological disorder and brain-protecting action and is useful as a therapeutic agent for neurological disorder, particularly as a brain- protecting agent.
This novel compound is an aminoalcohol derivative represented by formula I [R1 is an alkyl, an alkenyl, a cycloalkyl, an aryl; R2 is an alkyl, a hydroxyalkyl, an alkenyl, a hydroxyalkenyl; R3 is a group of formula II, formula III (R5 and R6 are each H, an alkyl, piperidino); R4 is H, an alkyl, an amino, an alkoxy, carboxyl; n is 1-4] or its pharmaceutically acceptable salt, typically (1S, 2S)-2-decanoylamino-3-morpholino-1-phenyl-1-propyl acetate. The compound of formula I is prepared, for example, by esterification of the hydroxyl group in the compound of formula IV with a carboxylic acid or its reactive derivative corresponding to CO-(CH2)n-R4.
JINBO MASAYUKI
FUJIWARA MICHIHIRO
