AMINOALKYLBENZENE COMPOUND

Japanese Patent JP2002047264

A

To provide an intermediate for synthesis of serine protease inhibitor and a method for producing the same.

In order to produce a compound represented by general formula (I) [W1 is a protecting group for N-terminus; A2 represents structural fragments of formulas IIIa, IIIb or IIIc (wherein (p) is an integer of 0-2; (m) is an integer of 1-4; Y is methylene or the like; R3 is a 1-4C alkyl or the like; R5 is H or a 1-4C alkyl), (n) is an integer of 0-4; and Q1 is a protected amidino group or the like], an N-terminus-protected amino acid represented by the general formula: W1-A2-OH (W1 and A2 are defined as stated above) is allowed to react with a compound represented by general formula (II) (wherein (n) and Q1 are defined as stated above).

JP3003187	The manufacturing process of a 含窒素 hetero ring
WO/1992/004329	PROCESS FOR PRODUCING NITROGENOUS HETEROCYCLE
WO/1998/018461	INTEGRIN ANTAGONISTS

ANTONSSON KARL THOMAS (SE)
BYLUND RUTH ELVY (SE)
GUSTAFSSON NILS DAVID (SE)
NILSSON NILS OLOV INGEMAR (SE)

JP2001158596A

February 12, 2002

June 02, 1994

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ASTRAZENECA AB (SE)

C07D239/12; A61K31/397; A61K31/445; A61K38/00; A61K38/04; A61K38/05; A61K38/06; A61K38/55; A61P1/00; A61P7/02; A61P11/02; A61P11/06; A61P17/00; A61P19/02; A61P25/28; A61P29/00; A61P43/00; C07C237/12; C07C257/16; C07C257/18; C07C271/64; C07D205/04; C07D207/09; C07D211/16; C07D211/26; C07D211/60; C07D239/14; C07K1/10; C07K2/00; C07K5/00; C07K5/02; C07K5/04; C07K5/06; C07K5/062; C07K5/065; C07K5/078; C07K5/08; C12N9/99; C07C257/00; C07D205/00; C07D207/00; C07D211/00; C07D239/00; (IPC1-7): C07C257/16; A61P7/02; A61P43/00; C07C257/18; C07D205/04; C07D207/09; C07D211/16; C07D239/14

Chika Takagi (1 person outside)

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