NEW MATERIAL:The compound of formula I [Z is A, group of formula II, CR2=N, etc., (A is O, S, SO, etc.; R2 and R3 are H, OH, halogen, etc.; R2 and R3 may be independently 3-6C cycloalkyl); R1 is H, 1-5C alkyl, alkanoyl or benzyl; (m) is 1-3; X is H, 1-12C alkyl, alkoxy, etc.; (n) is 0-12; Y is 1-12C alkyl, alkoxy, etc.; the positions of substituent X and amino group are arbitrary substitutable position on benzene ring].
EXAMPLE: 5N-benzylamino-1,3-dihydro-2,1,3-benzothiazole-2,2-dioxide hydrochloride.
USE: Medicine for inflammatory diseases, allergic diseases and cardiovascular diseases.
PREPARATION: The objective compound can be produced by using benzosultam of formula III as a starting substance, nitrating and then hydrogenating the substance, adding carbonyl compound and subjecting the product to reducing amination.
SATAKE KUNIO
ANDO KAZUO
WAKABAYASHI HIROAKI
