AMINOCARBOXYLATE LIGAND HAVING SUBSTITUTED AROMATIC AMIDE MOIETY

Japanese Patent JP2538165

B2

PURPOSE: To obtain a metallic chelating ligand capable of forming a metallic chelate complex useful as a diagnostic agent by substituting nitrogen atom in an aminocarboxylate with a substituted aromatic amide group.
CONSTITUTION: This ligand is obtained by substituting nitrogen atom of an aminocarboxylate ligand capable of complexing with a paramagnetic metallic ion and forming a metallic chelate complex with a substituted aromatic amide group, e.g. a group represented by formula I [A1 is (CH2)m, or a single bond; R1 and R2 are each H, an alkyl, NO2, NH2, NHC(=S)NHR12, NCS, C(=O)NR3R4 or NR3COR9 (R3 and R4 are each H, an alkyl, an aryl, an alkoxy, etc.; R9 is an alkyl or a hydroxyalkyl; R12 is H or R9), with the proviso that R1 and R2 are not simultaneously H; R13 is R3 or R4; (m) and (m') are each 1-5], e.g. a compound represented by formula II. The ligand is complexed with a paramagnetic metallic atom and used as a relaxation enhancer for a magnetic resonance image or complexed with a lanthanide and used as a chemical transfer agent in magnetic resonance image and magnetic resonance in vivo spectrometry and further for forming a contrast agent for X-ray imaging, radionuclide imaging and ultrasonic imaging.

RADOHAKURISHUNA PIRAI
EDOMUNDO AARU MARINERI
RAMACHANDORAN ESU RANGANASAN
MAIKERU EFU TSUIIDORU
SANNIN KAN

JP20509792A

September 25, 1996

July 31, 1992

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BURATSUKO INTERN BV

A61K49/04; A61K49/06; A61K51/04; C07C335/20; C07D257/02; A61K49/00; C07F5/00; (IPC1-7): A61K49/00; A61K49/04; C07C335/20; C07D257/02; C07F5/00

JPH05229998A
JPH03291260A
JPH03203282A

Ｊ．ＣＨＥＭ．ＳＯＣ．ＰＥＲＫＩＮＴＲＡＮＳ２ＮＯ．１（１９９１）Ｐ．８７−８９
ＭＵＣＬ．ＭＥＤ．ＢＩＯＬ．ＡＤＶ．ＰＲＯＣ．ＷＯＲＬＤＣＯＮＧＲ．３ＲＤＭＥＥＴＩＮＧＤＡＴＥ１９８２ＶＯＬＵＭＥ１Ｐ．２２７−２２９（１９８３）（ＣＨＥＭＩＣＡＬＡＢＳＴＲＡＣＴＳ９８：１７５６５１）

Aoyama Ryo (1 person outside)

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