NEW MATERIAL:The titled compound shown by the formula I [R1 is lower alkyl, or aralkyl; R2 is H, or aralkyl having lower alkoxy at phenyl ring part; R3 is H, or lower alkoxy; R and Q are H, or (substituted)alkyl, or P and R form heterocyclic ring through N, with the proviso that P=Q≠H; R4' is OH, or lower alkoxy; X is anion part].
EXAMPLE: 2-Benzyl-6-benzylamino-7-methoxy-1-veratryl-isoquinoliniumbromide.
USE: A drug and its intermediate. Having improved antimicrobial action, antispasmodic action, analgesic action, anti-inflammatory action, coccidiostat action, and carcinostatic action.
PREPARATION: 1mol equivalent isoquinolinium derivative shown by the formula II(R4 and R5 are lower alkoxy or both are bonded to form methylenedioxy) is reacted with 4W60mol equivalent amine shown by the formula III, to give a compound shown by the formula I .
NARUTO SHIYUNSUKE
MIZUTA YASUYUKI
