ナトリウム/プロトン交換体(NHE)の阻害剤として有用なアミノステロール化合物、同阻害剤を使用する薬学的方法および組成物、ならびに化合物のNHE阻害効果を評価する方法

Title:

Document Type and Number:

Japanese Patent JP4104164

Kind Code:

B2

Abstract:

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and essays for evaluating a compound's therapeutic activity are also disclosed.

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Inventors:

Zaslov Michael
Thinner ann
Kinney William
Williams john
Lao Mina
Anderson mark
Mclaren michael
Jones Stephen

Application Number:

JP50230797A

Publication Date:

June 18, 2008

Filing Date:

June 07, 1996

Export Citation:

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Assignee:

Genera Corporation

International Classes:

A61K31/575; A61P31/04; C07J41/00; A61P31/10; A61P31/12; A61P35/00; A61P43/00; G01N33/48; G01N33/50

Foreign References:

US5192756

Attorney, Agent or Firm:

Hidesaku Yamamoto

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