Title:
AMORPHIZED 7-CHLORO-5-HYDROXY-1-[2-METHYL-4-(2-METHYLBENZOYLAMINO) BENZOYL]-2,3,4,5-TETRAHYDRO-1H-BENZOAZEPINE AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
Japanese Patent JP2018168080
Kind Code:
A
Abstract:
To provide an amorphous body of tolvaptan having high safety to human bodies and having an improved elution rate.SOLUTION: The present invention provides a method for producing amorphized 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino) benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine. The method includes the steps of (A) dissolving 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino) benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine in a solvent mixture of acetone and ethanol to obtain a solution, and (B) distilling away the solvent from the solution.SELECTED DRAWING: Figure 3
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Inventors:
YAGI HIROSHI
IDO TAKAHIRO
NAKAGAWA TOMOAKI
HASHIMOTO KAZUHIDE
ISODA HIDEYUKI
HSU HULIN
IDO TAKAHIRO
NAKAGAWA TOMOAKI
HASHIMOTO KAZUHIDE
ISODA HIDEYUKI
HSU HULIN
Application Number:
JP2017064956A
Publication Date:
November 01, 2018
Filing Date:
March 29, 2017
Export Citation:
Assignee:
SHIZUOKA COFFEIN CO LTD
KOA SHOJI CO LTD
KOA SHOJI CO LTD
International Classes:
C07D223/16; A61K9/20; A61K31/55; A61K47/12; A61K47/36; A61K47/38; A61P1/16; A61P3/10; A61P7/00; A61P7/10; A61P9/00; A61P9/04; A61P9/12; A61P43/00
Attorney, Agent or Firm:
Patent business corporation Tsukuni