Title:
両親媒性直鎖状ペプチド／ペプトイドおよびそれを含むヒドロゲル
Document Type and Number:
Japanese Patent JP5833096
Kind Code:
B2
Abstract:
The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hy-drogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear pep-tide/peptoid is capable of forming, a hydrogel. These peptides/peptoids include short amphi-philic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such pep-tides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly: A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.
Inventors:
Haother, Charlotte A. E.
Koe, Ulung Gondo Cusmo
Mishra, Archana
Koe, Ulung Gondo Cusmo
Mishra, Archana
Application Number:
JP2013502540A
Publication Date:
December 16, 2015
Filing Date:
December 15, 2010
Export Citation:
Assignee:
AGENCY FOR SCIENCE,TECHNOLOGY AND RESEARCH
International Classes:
C07K7/06; A61K8/02; A61K8/64; A61K9/06; A61K35/12; A61K45/00; A61K47/42; A61K47/48; A61L27/00; A61L31/00; A61P43/00; B01J13/00; B01J20/26; B01J20/30; C07K5/083; C07K5/103; C12N5/071
Domestic Patent References:
| JP2006509492A | ||||
| JP2010500568A | ||||
| JP2007513174A | ||||
| JP2005515796A | ||||
| JP2008508292A |
Foreign References:
| WO2008131052A1 | ||||
| US20070048752 | ||||
| EP1457558A1 | ||||
| WO2009148947A1 | ||||
| US20090297450 |
Other References:
Journal of the American Chemical Society,2006年,Vol.128,p.13324-13325
Chemical Communications,2010年,Vol.46,p.979-981
Journal of Biomedical Engineering,2010年 2月,Vol.27, No.1,p.113-115
Journal of Clinical Reharbilitative Tissue Engineering Reseach,2009年,Vol.13, No.34,p.6667-6670
Chemical Communications,2010年,Vol.46,p.979-981
Journal of Biomedical Engineering,2010年 2月,Vol.27, No.1,p.113-115
Journal of Clinical Reharbilitative Tissue Engineering Reseach,2009年,Vol.13, No.34,p.6667-6670
Attorney, Agent or Firm:
Kurata Masatoshi
Yoshihiro Fukuhara
Makoto Nakamura
Nobuhisa Nogawa
Toshio Shirane
Takashi Mine
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Morisezo Iseki
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori
Yoshihiro Fukuhara
Makoto Nakamura
Nobuhisa Nogawa
Toshio Shirane
Takashi Mine
Kocho Chojiro
Naoki Kono
Katsu Sunagawa
Morisezo Iseki
Tatsushi Sato
Takashi Okada
Mihoko Horiuchi
Takenori Masanori