Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
ANALYSIS OF POLYMER INCLUDING POLYMER UNIT
Document Type and Number:
Japanese Patent JP2021072834
Kind Code:
A
Abstract:
To provide an estimation method of a sequence of a polymer unit in a polymer of DNA, and a measurement method of an ion current flowing in a nanopore.SOLUTION: There is provided a method for estimating a sequence of a polymer unit in a polymer from measurement of at least one series related to a polymer, in which respective measured values rely on k-mers which are groups of k polymer units, k being a positive integer. The method comprises: a step for providing a model including transition weighting indicating possibility of transition from an origin k-mer to a destination k-mer for a possible set of k-mers, and discharge weighting related to each k-mer indicating possibility of observing a given measured value about the k-mer; and a step for analyzing the series of measurement using an analysis technique of referring to the model, and on the basis of likelihood at which, the series of measurement is predicted by the model generated by the sequence of the polymer unit, estimating at least one estimated sequence of the polymer unit in the polymer.SELECTED DRAWING: None

More Like This:
WO/2010/001358DIAGNOSTIC POLYMORPHISMS FOR CARDIAC DISEASE
JP2018134038BIOMARKER FOR PATIENT SELECTION SHOWING EFFICACY FOR CANCER TREATMENT WITH PD-1 PATHWAY INHIBITOR
JP2008515416Universal primers and their use for detecting and identifying plant materials in complex mixtures
Inventors:
STUART WILLIAM REID
GAVIN HARPER
CLIVE GAVIN BROWN
JAMES ANTHONY CLARKE
ANDREW JOHN HERON
Application Number:
JP2021014055A
Publication Date:
May 13, 2021
Filing Date:
February 01, 2021
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
OXFORD NANOPORE TECH LTD
International Classes:
C12Q1/68; C12M1/00; C12Q1/34; G01N27/00; G16B30/10
Domestic Patent References:
JP2005257687A2005-09-22
JP2006119140A2006-05-11
JP2010524436A2010-07-22
Other References:
JOHN J. KASIANOWICZ: "Nanoscopic Porous Sensors", ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, vol. 1, no. 1, JPN6016031936, 2008, pages 737 - 766, XP055020130, ISSN: 0004702480, DOI: 10.1146/annurev.anchem.1.031207.112818
J. AM. CHEM. SOC., vol. 132, no. 50, JPN6022004328, 2010, pages 17961 - 17972, ISSN: 0004910561
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Yasuhito Suzuki



 
Previous Patent: 核酸増幅

Next Patent: 安定性が向上したＰＤＧＦ及びＶＥＧＦアプタマー並びにＰＤＧＦ及びＶ...