Title:
プロテアーゼ活性および肝障害のための動物モデル
Document Type and Number:
Japanese Patent JP2007505603
Kind Code:
A
Abstract:
The present invention relates to a non-transgenic, non-human animal useful as a model for protease activity and for liver damage, including steatosis.
Inventors:
Kalkeli, Gururadi
Kwon, Anne
Kwon, Anne
Application Number:
JP2006526392A
Publication Date:
March 15, 2007
Filing Date:
September 13, 2004
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS, INC.
International Classes:
C12N15/09; A01K67/027; A61K31/4709; A61K31/7056; A61K38/05; A61K45/00; A61P1/16; A61P3/06; A61P31/14; A61P43/00; C07K14/18; C12N5/071; C12N5/10; C12Q1/02; G01N33/15; G01N33/50; A61K38/55; A61K
Other References:
JPN6010036459, Ｊｏｕｒｎａｌ ｏｆ Ｖｉｒｏｌｏｇｉｃａｌ Ｍｅｔｈｏｄｓ（１９９８），Ｖｏｌ．７２，ｐ．１０９−１１５
JPN6010036460, Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ（２００２），Ｖｏｌ．１２２，Ｎｏ．２，ｐ．３５２−３６５
JPN7010001974, Ｊ Ｍｅｄ Ｖｉｒｏｌ．（２０００），Ｖｏｌ．６２，Ｎｏ．３，ｐ．３０８−３１７
JPN6010036461, Ｊ Ｇａｓｔｒｏｅｎｔｅｒｏｌ Ｈｅｐａｔｏｌ．（２００２），Ｖｏｌ．１７，Ｎｏ．４，ｐ．３９４−４００
JPN6010036462, Ｃａｎｃｅｒ Ｇｅｎｅ Ｔｈｅｒ．（２００１），Ｖｏｌ．８，Ｎｏ．８，ｐ．５７３−５７９
JPN6010036460, Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ（２００２），Ｖｏｌ．１２２，Ｎｏ．２，ｐ．３５２−３６５
JPN7010001974, Ｊ Ｍｅｄ Ｖｉｒｏｌ．（２０００），Ｖｏｌ．６２，Ｎｏ．３，ｐ．３０８−３１７
JPN6010036461, Ｊ Ｇａｓｔｒｏｅｎｔｅｒｏｌ Ｈｅｐａｔｏｌ．（２００２），Ｖｏｌ．１７，Ｎｏ．４，ｐ．３９４−４００
JPN6010036462, Ｃａｎｃｅｒ Ｇｅｎｅ Ｔｈｅｒ．（２００１），Ｖｏｌ．８，Ｎｏ．８，ｐ．５７３−５７９
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo