Title:
ANTAGONIST OF APOPTOSIS INHIBITION PROTEIN (IAP)
Document Type and Number:
Japanese Patent JP2018162256
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a compound for adjusting activity of apoptosis inhibition protein (IAP).SOLUTION: There is provided a compound of the formula A-I. Wand Weach represents O, S or N or C which may be substituted, Rrepresents H, C-Calkyl or the like, X, Xrepresent O, S or N or C which may be substituted or the like or selected from C and N independently, and are members of a condensed ring, m represents 0, 1 or 2, -U- is -NHC(=O)-, -C(=O)NH- or the like, Rrepresents C-Calkyl group or the like, Rrepresents -NHR, -ORor the like and Rrepresents H, C-Calkyl or the like.SELECTED DRAWING: None
Inventors:
NICHOLAS DAVID PETER COSFORD
MITCHELL DENNIS VAMOS
MITCHELL DENNIS VAMOS
Application Number:
JP2018101004A
Publication Date:
October 18, 2018
Filing Date:
May 25, 2018
Export Citation:
Assignee:
SANFORD BURNHAM MED RES INSTITUTE
International Classes:
C07D487/04; A61K31/395; A61K31/5365; A61K31/55; A61K31/551; A61K31/553; A61K31/554; A61P1/00; A61P1/04; A61P1/16; A61P3/02; A61P3/10; A61P5/14; A61P7/04; A61P7/06; A61P9/00; A61P9/10; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C07D487/14; C07D498/04; C07D513/04; C07D519/00
Domestic Patent References:
| JP2008505976A | 2008-02-28 | |||
| JP2007522116A | 2007-08-09 | |||
| JP2008545780A | 2008-12-18 | |||
| JP2011516581A | 2011-05-26 | |||
| JP2003519629A | 2003-06-24 |
Foreign References:
| WO2010120476A2 | 2010-10-21 |
Other References:
DATABASE REGISTRY, JPN7017003094, 2009, ISSN: 0003986571
ZHANG, BIN; NIKOLOVSKA-COLESKA, ZANETA; ZHANG, YAN; BAI, LONGCHUAN; QIU, SU; YANG, CHAO-YIE; SUN, HA: "Design, Synthesis, and Evaluation of Tricyclic, Conformationally Constrained Small-Molecule Mimetics", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51(23), JPN6017036698, 2008, pages 7352 - 7355, ISSN: 0003986572
ZHANG, BIN; NIKOLOVSKA-COLESKA, ZANETA; ZHANG, YAN; BAI, LONGCHUAN; QIU, SU; YANG, CHAO-YIE; SUN, HA: "Design, Synthesis, and Evaluation of Tricyclic, Conformationally Constrained Small-Molecule Mimetics", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51(23), JPN6017036698, 2008, pages 7352 - 7355, ISSN: 0003986572
Attorney, Agent or Firm:
Kazuhiro Kiyohara