Title:
抗αvβ6抗体
Document Type and Number:
Japanese Patent JP4473117
Kind Code:
B2
Abstract:
A monoclonal antibody or an antigen binding fragment thereof that (a) specifically binds to ±v²6 but does not bind other av integrins; and (b) does not inhibit the binding of ²6 to latency associated peptide (LAP) with an IC50 value lower than that of 10D5.
Said monoclonal antibody, wherein the antibody comprises
a) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6. 2A1 (ATCC accession number PTA-3896) or
b) the same heavy and light chain polypeptide sequences as an antibody produced by hybridoma 6.2E5 (ATCC accession number PTA-3897). The disclosure also relates to uses of same and to compositions comprising same.
Inventors:
Violet, Sheria M.
Vienna Leb, Paul H.
Simon, Kenneth Jay.
Sheppard, Dean
Leon, Diane Earl.
Vienna Leb, Paul H.
Simon, Kenneth Jay.
Sheppard, Dean
Leon, Diane Earl.
Application Number:
JP2004508275A
Publication Date:
June 02, 2010
Filing Date:
March 13, 2003
Export Citation:
Assignee:
Biogen Idec MA Inc.
The Regents of The University of California
The Regents of The University of California
International Classes:
C12N15/09; A61K39/395; A61K47/48; A61K51/10; A61P1/16; A61P11/00; A61P13/12; A61P17/02; A61P17/06; A61P35/00; C07K7/08; C07K14/00; C07K16/18; C07K16/28; C12N5/10; C12N5/12; C12Q1/02; G01N33/574; G01N33/68; C12N
Domestic Patent References:
| JP2001513333A |
Foreign References:
| WO1991016927A1 | ||||
| WO2001081421A1 |
Other References:
Biochem.Biophys.Res.Commun.,Vol.288(2001)p.610-618
J.Biol.Chem.,Vol.269,No.9(1994)p.6940-6948
J.Cell Sci.,Vol.108(1995)p.2241-2251
Cell,Vol.96(1999)p.319-328
J.Biol.Chem.,Vol.269,No.9(1994)p.6940-6948
J.Cell Sci.,Vol.108(1995)p.2241-2251
Cell,Vol.96(1999)p.319-328
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita