Title:
癌、関節炎および網膜症の治療用抗脈管形成薬
Document Type and Number:
Japanese Patent JP4254972
Kind Code:
B2
Abstract:
Peptides having the formula: T-Gly-Val-D-Ile-Thr-Arg-Ile-U, V-Gly-D-Val-Ile-D-Thr-D-Arg-D-Ile-W, X-D-Arg-D-Ile-D-Arg-D-Thr-Ile-D-Val-Y, and Z-Gly-Val-Ile-Thr-Arg-Ile-U wherein T is absent or is selected from N-protecting group and a polypeptide of up to 12 amino acid residues optionally terminated with an N-protecting group; U is selected from Arg and Arg-NR<1>R<2> wherein R<1> and R<2> are independently selected from hydrogen and alkyl of one to four carbon atoms; V is absent or an N-protecting group; W is selected from D-Arg and D-Arg-NR<1>R<2>; X is absent or an N-protecting grou; Y is selected from Gly and Gly-NR<1>R<2>; and Z is 1-12 amino acid residues optionally terminated with an N-protecting group wherein at least one of the amino acid residues is a D-amino acid residue inhibit angiogenesis and are useful in the treatment of disease states such as cancer, arthritis, macular degeneration and diabetic retinopathy in which angiogenesis plays a role.
Inventors:
Henkin, Jack
Booke, Noel Pee
Dawson, David Doublet
Schneider, Andrew Jei
Booke, Noel Pee
Dawson, David Doublet
Schneider, Andrew Jei
Application Number:
JP54076598A
Publication Date:
April 15, 2009
Filing Date:
March 16, 1998
Export Citation:
Assignee:
Abbot Laboratories
Northwestern University
Northwestern University
International Classes:
A61P17/06; A61K38/00; A61P27/02; C07K11/00; A61P29/00; A61P35/00; C07K7/06; C07K7/08; C07K14/47; C07K14/78
Domestic Patent References:
| JP4288020A |
Foreign References:
| WO1993016716A1 |
Other References:
The Journal of cell biology. 1993, Vol.122, No.2, p.497-511
Biochemical and biophysical research communications. 1995, Vol.214, No.2, p.685-693
Biochemical and biophysical research communications. 1995, Vol.214, No.2, p.685-693
Attorney, Agent or Firm:
Kayo Shiina
Yoshio Kawaguchi
Naoya Fushimi
Natsuo Tanaka
Yoshio Kawaguchi
Naoya Fushimi
Natsuo Tanaka