ANTI-IGF-I RECEPTOR ANTIBODY

Title:

ANTI-IGF-I RECEPTOR ANTIBODY

Document Type and Number:

Japanese Patent JP2011041564

Kind Code:

A

Abstract:

To provide antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of these with cytotoxic agents, which specifically bind to and inhibit insulin-like growth factor-I receptor, antagonize the effects of IGF-I, IGF-II, and serum on the growth and survival of tumor cells, and which are substantially devoid of agonist activity.

The antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of IGF-I receptor, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma, prostate cancer, and pancreatic cancer. The derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of IGF-I receptor.

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Inventors:

SINGH RAJEEVA
TAVARES DANIEL J
DAGDIGIAN NANCY E

Application Number:

JP2010190561A

Publication Date:

March 03, 2011

Filing Date:

August 27, 2010

Export Citation:

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Assignee:

IMMUNOGEN INC

International Classes:

C12N15/09; A61K31/337; G01N33/534; A61K31/395; A61K39/395; A61K45/00; A61K47/48; A61P35/00; A61P43/00; C07K16/18; C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/06; C12N5/10; C12N5/16; C12N15/13; C12N15/62; C12P21/02; C12P21/08; G01N33/15; G01N33/50; G01N33/53; G01N33/574

Domestic Patent References:

JP2004531217A	2004-10-14
JP2005536181A	2005-12-02
JP2004531217A	2004-10-14
JP2005536181A	2005-12-02

Other References:

JPN6009029225; Ｂｉｏｃｈｅｍｉｃａｌ　　ａｎｄ　Ｂｉｏｐｈｙｓｉｃａｌ　Ｒｅｓｅａｒｃｈ　ＣｏｍｍｕｎｉｃａｔｉｏｎｓＶｏｌ．１７１，Ｎｏ．３, 1990, ｐ．１２４４-１２５１
JPN6009029223; 抗体工学入門初版第１刷, 1994, ２８-２９, 株式会社地人書館
JPN6009029224; 抗体工学入門初版第１刷, 1994, ２３０-２３１, 株式会社地人書館
JPN6009029225; Ｂｉｏｃｈｅｍｉｃａｌ　　ａｎｄ　Ｂｉｏｐｈｙｓｉｃａｌ　Ｒｅｓｅａｒｃｈ　ＣｏｍｍｕｎｉｃａｔｉｏｎｓＶｏｌ．１７１，Ｎｏ．３, 1990, ｐ．１２４４-１２５１
JPN6009029223; 抗体工学入門初版第１刷, 1994, ２８-２９, 株式会社地人書館
JPN6009029224; 抗体工学入門初版第１刷, 1994, ２３０-２３１, 株式会社地人書館

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka

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