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Patent Searching and Data


Title:
ANTI-INFLAMMATORY ARYL DERIVATIVE
Document Type and Number:
Japanese Patent JPH0288553
Kind Code:
A
Abstract:

NEW MATERIAL: (E)-N-{1(S)-methyl-3-[3-(4-fluorophenoxy)phenyl]prop-2-en-l- yl}acetohydroxamic acid and its salt.

USE: This new material is useful as an inhibitor of lipoxygenase and cyclo- oxygenase and also useful for treating and preventing symptons such as convulsions, allergy, fever, inflammatory, platelet coagulation or pain relief.

PROCESS: E-N, o-bis(acetyl)-N-{1(S)-methyl-3-[3-(4-fluorophenoxy)phenyl]prop-2-en-l- yl}hydroxylamine is bis-acetylated by using acetyl chloride in the presence of a base such as pyridine in a neutral solvent and, subsequently, anhydrous K2CO3 is used in alcohol to de-0-acetylate the obtained product to obtain a novel compd.


Inventors:
UIRIAMU POORU JIYAKUSON
JIYON ANSONII SARUMON
Application Number:
JP18162989A
Publication Date:
March 28, 1990
Filing Date:
July 13, 1989
Export Citation:
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Assignee:
WELLCOME FOUND
International Classes:
A61K31/165; A61P7/02; A61P25/04; A61P25/08; A61P29/00; A61P37/08; C07C259/06; (IPC1-7): A61K31/165; C07C259/06
Attorney, Agent or Firm:
Akira Asamura (3 outside)