Title:
抗前立腺幹細胞抗原(PSCA)抗体組成物及び使用方法
Document Type and Number:
Japanese Patent JP4028237
Kind Code:
B2
Abstract:
The invention provides isolated anti-prostate stem cell antigen (PSCA) antibodies that internalize upon binding to PSCA on a mammalian in vivo. The invention also encompasses compositions comprising an anti-PSCA antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-PSCA antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-PSCA antibodies. The invention encompasses a method of producing the anti-PSCA antibodies. Other aspects of the invention are a method of killing a PSCA-expressing cancer cell, comprising contacting the cancer cell with an anti-PSCA antibody and a method of alleviating or treating a PSCA-expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-PSCA antibody to the mammal.
Inventors:
DuBois, Bridget
Keller, Gilbert-Andre
Köppen, Hartmut
Rusky, Lawrence, A.
Keller, Gilbert-Andre
Köppen, Hartmut
Rusky, Lawrence, A.
Application Number:
JP2001541063A
Publication Date:
December 26, 2007
Filing Date:
October 27, 2000
Export Citation:
Assignee:
GENENTECH,INC.
International Classes:
C07K16/30; C12N15/09; A61K31/337; A61K31/537; A61K39/395; A61K45/00; A61P35/00; C07K14/47; C07K14/705; C07K16/18; C07K16/46; C07K19/00; C12N1/21; C12N5/10; C12N15/02; C12P21/02; C12P21/08
Domestic Patent References:
| JP2002531082A |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori