PURPOSE: To obtain an antiallergic agent, containing a steroidal compound having the steroidal skeleton in which the 21-position is substituted with an acylthio group or amide group derived from an N-acylamino acid having a specific structure as an active ingredient and effective against allergic diseases with hardly any side effects.
CONSTITUTION: An anti-inflammatory agent containing a 21-substituted sterordal compound expressed by the formula (R us H, alkyl, alkoxy or phenyl; R2 is OH or acyloxy; R3 is H or alkyl or R2 and R3 together may form alkylidenedioxy; X1 and X2 are H or halogen; Y1 and Y2 are methylene or S; Z is S or imino; the wavy line indicates that the steric configuration may be either of α or β and the broken line between the 1-and 2-positions indicates that the bond may be double bond) {e.g. 9-fluoro-21[2-(formylamino)-4- methylthio-1-oxobutylthio]-11β, 17α-isopropylidenedioxypregna-1,4-diene-3,20-dione} as an active ingredient. The aforementioned medicine has strong pharmacological action capable of providing recovery in the early stage with extremely rare side effects.
MORIWAKI SHIGERU
TSUCHIYA SHUICHI
HORI KIMIHIKO
SUZUKI YASUTO
