To obtain an antiallergic agent which contains a specific dibenzoxepin derivative as an active ingredient, has excellent antiallergic action and is effective against bronchial asthma, allergic rhinitis, atopic dermatitis, urticaria and the like.
A dibenz[b,e]oxepin derivative of formula I [A is a single bond, CH=CH, (CH2)n ((n) is an integer of 1-3); R1 and R2 are each H, a lower alkyl] and its pharmaceutically permissible salts are used as an antiallergic agent. The compound of formula I is prepared, for example, by protecting the carboxyl group in the compound of formula II with a proper protecting group R3, oxidizing the product of formula III and deprotecting the oxidized product of formula IV. As a salt of the compound of formula I, Na salt, K salt, Mg salt, ammonium salt, morpholinium salt, a lysine salt or of a histidine salt are cited.
OISHI TAKAYOSHI
MAGARA HIROSHI
KOBAYASHI HIROYUKI
KOBAYASHI SATOSHI
YASUZAWA TORU
YAMAGUCHI KAZUO
ISHII SHIYUUE
OOMORI TAKEMORI
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