PURPOSE: To provide novel antibiotics useful for the theraspies of mycotic infectious diseases by Candida, Aspergillus, etc.
CONSTITUTION: The objective antibiotics are expressed by formula I (X is of formula II or III) [i.e., WAP-5044A (X is of formula III) and WAP-5044C (X is of formula II)] or their salts. These compounds can be obtained by culturing, in a medium, microorganisms having productive ability of antibiotic(s) WAP-5044A and/or WAP-5044C [e.g. WAP-5044 strain (FERM P-12554)] to produce and accumulate the antibiotic(s) in the cultured product, followed by collecting it (them). A novel derivative, 2-amino-4-aminoxy-3-trans-butenoic acid of formula IV can be obtained by treating the antobiotic WAP-5044C with alginase. This compound of formula IV, which is unstable, can cause intramolecular rearrangement and intramolecular dehydration to effect ready conversion to β-cyanolamine of formula V.
KATOU AZUSA
NAKATANI SEIGO
AIBA TAKESHI
OHASHI YOSHITAMI
GOTO MASAYOSHI
