Title:
抗体、ポリペプチドおよびその使用
Document Type and Number:
Japanese Patent JP5336566
Kind Code:
B2
Abstract:
A method of inhibiting angiogenesis in an individual in need thereof comprising administering an antibody that selectively binds to the extracellular region of human magic roundabout (MR) to the individual. An antibody that has the amino acid sequences i) to iii), the amino acid sequences iv) to vi), or the amino acid sequences i) to vi). i) S A S S S V S Y M Y ii) L T S N L A S iii) Q Q W S S N P L T iv) D Y N L N v) V I N P N Y G T T S Y N Q K F K G vi) G R D Y F G Y. A method of inhibiting angiogenesis in an individual in need thereof comprising administering the extracellular domain (residues 1-467) of MR, or a fragment thereof that inhibits angiogenesis, to the individual. A method of inhibiting endothelial cell migration and/or proliferation comprising administering the extracellular domain of MR, or a fragment thereof that inhibits endothelial cell migration and/or proliferation.
Inventors:
Roy Bicknell
Stephen Sacking
Lorna Marie Diet Stewart
Stephen Sacking
Lorna Marie Diet Stewart
Application Number:
JP2011207275A
Publication Date:
November 06, 2013
Filing Date:
September 22, 2011
Export Citation:
Assignee:
CANCER RESEARCH TECHNOLOGY LIMITED
International Classes:
C12N15/09; A61P9/00; A61P35/00; C07K14/705; C07K16/18; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; A61K38/00; A61K39/395; A61K51/00; C12P21/08
Foreign References:
| WO2002036771A1 |
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro