Title:
ＧＬＰ−１Ｒに特異的に結合する抗体およびそのＧＬＰ−１との融合タンパク質
Document Type and Number:
Japanese Patent JP6749235
Kind Code:
B2
Abstract:
Disclosed in the present invention is an antibody specifically binding to GLP-1R and a fusion protein thereof with GLP-1. The fusion proteins can effectively bind to a human GLP-1R receptor and activate a receptor signaling pathway, thus are useful for treating diabetes, excessive weight, obesity and related disorders thereof
Inventors:
Cheng hang
Squawian Jing
Hurts hang
Queer Offing Wang
Change Ang Yao
Squawian Jing
Hurts hang
Queer Offing Wang
Change Ang Yao
Application Number:
JP2016533798A
Publication Date:
September 16, 2020
Filing Date:
August 01, 2014
Export Citation:
Assignee:
GM Ax Bio Farm LLC.
International Classes:
C12N15/13; A61K31/7088; A61K39/395; A61K48/00; A61P3/10; A61P43/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2013509182A | ||||
| JP2008537873A | ||||
| JP2008521869A |
Foreign References:
| US20120058116 | ||||
| WO2012154999A1 | ||||
| WO2009035577A1 | ||||
| WO2012137676A1 |
Other References:
Biochem Pharmacol (2018), Vol.150, p.46-53
Diabetes (2008), Vol.57, p.1926-1934
Diabetes (2004), Vol.53, p.2492-2500
Diabetes (2008), Vol.57, p.1926-1934
Diabetes (2004), Vol.53, p.2492-2500
Attorney, Agent or Firm:
Toru Ishikawa