Title:
SARSコロナウイルスに対する抗体
Document Type and Number:
Japanese Patent JP2009537143
Kind Code:
A
Abstract:
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV S protein, and that function to neutralize SARS-CoV. The invention also relates to antibodies that are bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-SARS-CoV S protein antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-SARS-CoV S protein antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
Inventors:
Bab Cook John S.
Prava Karl Berlues.
Cogolin Melissa
Prava Karl Berlues.
Cogolin Melissa
Application Number:
JP2009511112A
Publication Date:
October 29, 2009
Filing Date:
May 21, 2007
Export Citation:
Assignee:
Amgen Incorporated
International Classes:
C12N15/09; A01H5/00; A01K67/027; A61K39/395; A61K45/00; A61P11/00; C07K16/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki