Title:
TGFβに対する抗体
Document Type and Number:
Japanese Patent JP5174466
Kind Code:
B2
Abstract:
The present invention relates to antibody molecules, in particular antibody molecules that bindransformingrowthactor beta (TGFβ) and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralise TGFβ1, TGFβ2, and TGFβ3, so-called 'pan-specific' antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).
Inventors:
Red Better Stephen Earl.
Heart Celia Pee.
Holgate Robert G.
Germatus Lutz You.
Buchanan Katrina El.
Duncan Alexander Earl.
Finch Dona Kei.
Heart Celia Pee.
Holgate Robert G.
Germatus Lutz You.
Buchanan Katrina El.
Duncan Alexander Earl.
Finch Dona Kei.
Application Number:
JP2007554339A
Publication Date:
April 03, 2013
Filing Date:
February 08, 2006
Export Citation:
Assignee:
GENZYME CORPORATION
Optain, Incorporated
Optain, Incorporated
International Classes:
C12N15/09; A61K39/395; A61P35/00; A61P37/00; A61P43/00; C07K16/22; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12P21/08
Domestic Patent References:
| JP2002542770A |
Foreign References:
| WO2005007699A1 |
Other References:
J. Am. Soc. Nephrol., 2003, Vol.14, p.377-388
J. Immunol., 1989, Vol.142, p.1536-1541
J. Immunol., 1989, Vol.142, p.1536-1541
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue