ANTIBODIES, USES THEREOF AND CONJUGATES THEREOF

Title:

ANTIBODIES, USES THEREOF AND CONJUGATES THEREOF

Document Type and Number:

Japanese Patent JP2023017999

Kind Code:

A

Abstract:

To solve the problem that: since an antibody that is to be a candidate as a drug should have a low propensity to denature or aggregate, or disassociate into component fragments, there still remains a need for the development of further beneficial anti-PSMA antibodies.SOLUTION: An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequence given in SEQ ID NO:33, wherein SEQ ID NO:33 is: EVQLVQSGX9E X11KKPGASVKV SCKX24SGYTFT EYTIHWVX38QA X41GKGLEWIGN INPNX55GGTTY NOKFEDRX68TX70TVDKSTSTAY MELSSLRSED TAVYYCAAGW NFDYWGOGTT VTVSS, whereby the heavy chain variable domain comprises up to 3 amino acid sequence modifications between positions 1-30, 36-49, 67-98 and 105-115 of SEQ ID NO: 33.SELECTED DRAWING: None

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Inventors:

Timothy David Jones
Robert George Edward Holgate
Francis joseph car

Application Number:

JP2022183458A

Publication Date:

February 07, 2023

Filing Date:

November 16, 2022

Export Citation:

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Assignee:

Polycerix Limited

International Classes:

C12N15/13; A61K31/537; A61K38/08; A61K39/395; A61K47/68; A61K49/04; A61K49/16; A61K51/10; A61P13/08; A61P35/00; C07K16/28; C07K16/30; C07K16/46; C07K19/00; C12N5/10; C12N15/62; C12N15/85

Attorney, Agent or Firm:

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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