抗体、その使用及びそのコンジュゲート

Japanese Patent JP7179719

B2

An antibody or antigen-binding portion thereof which binds to PSMA and comprises a heavy chain variable domain comprising the sequence given in SEQ ID NO:33, wherein SEQ ID NO:33 is: EVQLVQSGX⁹E X¹¹KKPGASVKV SCKX²⁴SGYTFT EYTIHWVX⁸⁸QA X⁴¹ GKGLEWIGN INPNX⁵⁵GGTTY NOKFEDRX⁶⁸TX⁷⁰ TVDKSTSTAY MELSSLRSED TAVYYCAAGW NFOYWGOGTT VTVSS wherein: X⁹ is A or P X¹¹ is V or L X²⁴ is A or T X⁸⁸ is R or K X⁴¹ is P or H X⁵⁵ is N or Q X⁶⁸ is V or A; and X⁷⁰ is I or L whereby the heavy chain variable domain comprises up to 3 amino acid sequence modification(s) between positions 1-30, 36-49, 67-98 and 105-115 of SEQ ID NO: 33. The invention also provides compounds that include the antibody or antigen-binding portion thereof, such as conjugates, and their use in the treatment or diagnosis of diseases, in particular cancers, particularly prostate cancer.

JP3471006	[Title of Invention] A novel gene cloning method
WO/2001/060406	THERAPEUTIC METHODS THAT TARGET FRACTALKINE OR CX3CR1
WO/2022/098787	CELLS EXPRESSING A CHIMERIC RECEPTOR FROM A MODIFIED INVARIANT CD3 IMMUNOGLOBULIN SUPERFAMILY CHAIN LOCUS AND RELATED POLYNUCLEOTIDES AND METHODS

Timothy David Jones
Robert George Edward Holgate
Francis joseph car

JP2019516285A

November 29, 2022

June 06, 2017

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Polycerix Limited

C07K16/28; A61K31/537; A61K47/68; A61K49/00; A61K51/00; A61P35/00; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/63

JP2013512920A
JP2008504215A
JP2015533847A

WO2016033547A1
US20110311550

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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